Interpreting Mixtures Using Allele Peak Areas
نویسندگان
چکیده
منابع مشابه
Taking account of peak areas when interpreting mixed DNA profiles.
This paper establishes a logical framework for taking account of peak areas when interpreting mixed DNA STR profiles. The principles apply wherever such data are available but they are illustrated here by means of data which have been collected from made up mixtures of known concentrations analyzed at short tandem repeat loci. The data have led to some modeling assumptions which are used for nu...
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Genetic samples left at crime scenes involving rape often are mixtures containing DNA from both the victim and the perpetrator. It is of paramount importance that the genetic identity of the two contributors be resolved with a high degree of confidence. Thus, the probability of a suspect being the actual perpetrator can be evaluated; or in the absence of suspects, a database search can be condu...
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We introduce a new methodology, based upon probabilistic expert systems, for analysing forensic identification problems involving DNA mixture traces using quantitative peak area information. Peak area is modelled with conditional Gaussian distributions. The expert system can be used for ascertaining whether individuals, whose profiles have been measured, have contributed to the mixture. It can ...
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Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) facilitates determination of both the kinetic constants (k(off)) and the equilibrium constants (K(d)) of complex dissociation from a single experiment. A typical NECEEM electropherogram consists of two peaks and an "exponential bridge" between them, smoothly merging into the peaks. The values of k(off) and K(d) are usuall...
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DNA profiles from multiple-contributor samples are interpreted by comparing the probabilities of the profiles under alternative propositions. The propositions may specify some known contributors to the sample and may also specify a number of unknown contributors. The probability of the alleles carried by the set of people, known or unknown, depends on the allelic frequencies and also upon any r...
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ژورنال
عنوان ژورنال: Korean Journal of Applied Statistics
سال: 2010
ISSN: 1225-066X
DOI: 10.5351/kjas.2010.23.1.113